The natural product thiotimoline was isolated from the bark of Rosaceae Karlsbadensis rufo and its structure was unambiguously determined by time-resolved X-ray crystallomancy and spectroscopy. A total synthesis of thiotimoline was conducted following a convergent strategy. The pivotal transformations in this synthesis were a tandem Suzuki-Miyaura/Schinkenfaust radical cross-spifflication, a Szymankowszczyzna allylic inquisition and a [3+2+3+2] Puccini-Gershwin echocyclisation in A♭ major. An unnatural isomer of thiotimoline was also synthesised, and a theory of kairality and chronomers is presented and discussed.

The attractive physical properties and widespread availability of 2,4,6-trinitrotoluene (TNT) make it a popular commodity chemical. In accordance with the maxim that longer things are more appealing, it stands to reason that polymerising TNT should improve its utility. Herein, we report the first synthesis of poly(TNT), and an appraisal of its properties and commercial potential.

A one-step synthesis of taxol.

The following article constitutes a preliminary trial of a chemistry-specific artificial intelligence chatbot called “ChatCsp3”. This bot is being trained to take dense chemical jargon (left column) and make it accessible to the general public (right column).

We are fucking over undergrads so we’ve got more time to drink expensive beer.

The proper naming of chemical compounds is paramount for conducting science in a serious manner, as well as for the purpose of just screwing around (not to imply that there is any significant difference between the two). In this work, a more appropriate name for 3’-hydroxycinnamaldehyde is proposed.

Six things to do with a decommissioned NMR.

Supernatural products are just like any other molecules, only more so. This illiterature review presents a recap of supernatural products with structures that have been elucidated or reassigned in the last decade(ish).

We report the first total synthesis of the supernatural product monoalizeamine D via a 14-step pathway. Our synthetic approach relies heavily on photocatalysis and radical intermediates. By preparing both E and Z isomers of this compound, we have conclusively resolved the ambiguity concerning the orientation of the C15–C16 olefin.

It is well known fact in the scientific community that geologists frequently lick rocks to determine their mineral composition. With this paper we aim to formalize this procedure and establish a baseline scale enabling geologists to reliably classify their favourite rocks culinographically.

We report the first synthesis and comprehensive characterisation of hexazine, last in the series of 6-membered nitrogen heterocycles. A novel azide-azide click reaction was developed to facilitate this synthesis. Hexazine may serve as a non- carcinogenic alternative solvent to benzene, function as a mild amine-base, and even act as a weak nucleophile for further synthesis. The detailed exploration of such is left as an exercise for the reader.

 It is with sadness, confusion, and relief that the chemistry community prepares to farewell one of its most colourful members. Frank Furious (1974–TBA) was, and technically still is, an Austrian American synthetic chemist, known for his work in palladium catalysis, and for dancing naked on the bar at an ACS annual meeting in 1998. He is currently in a coma at St Ethylbert’s Hospital in Luton, following a serious lab accident earlier this week.

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Did you know that one in ten molecules suffers from electrile dysfunction? Electrile dysfunction (ED) is a mechanistic condition in which the electron density within a molecule becomes constricted, preventing it from reaching a functional group. The result is a loss of steric rigidity which quite frequently causes impaired reactivity. Conversely, rigor moietis (RI) can occur as a result of orbital scrambling. This work describes a treatment for ED and RI using energy transfer catalysis..

Icosahedral microcrystals were observed in a random experiment. Who cares about its formation mechanism when we can game instead? And as our research progresses, it appears that atoms share our philosophy. It was elucidated that chemical reactions occur on a chance based RNG system where all outcomes are equally possible.

Spectroscopy often yields messy spectra, littered with a myriad of impurities and unhelpful product peaks. Contrary to popular belief, this is not due to the author’s poor analytical skills. Whatever the reason might be, a cure is always better than prevention. Therefore, a completely new method of characterizing chemicals was developed.

Are you tired of cleaning glassware? Are your fingers burning from all that acetone? Do you wish that your lab partner would just shut up and stop spilling your hard-earned product on the floor? Well, we can’t prevent the last one, but with some novel equipment designed in collaboration with top boron chemists, interior designers, and glass blowers, we have revolutionized laboratory glassware. 

We have developed a cheap, sustainable and effective alternative to the oil bubbler/Schlenk line for the protection of air-sensitive reactions from atmospheric O2.