The Total Synthesis of Monoalizeamine D

Chemistry
Written By Günther Schlonk

Abstract: We report the first total synthesis of the supernatural product monoalizeamine D via a 14-step pathway. Our synthetic approach relies heavily on photocatalysis and radical intermediates. By preparing both E and Z isomers of this compound, we have conclusively resolved the ambiguity concerning the orientation of the C15–C16 olefin.

Günther Schlonk
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