You Twist Me Right Round Baby: The Total Synthesis of Mobiustrine A

Abstract: We report the total synthesis of the supernatural product mobiustrine A, starting from isoheptane. The key steps in our synthesis were a [2+2]+[2+2] cycloaddition, a Bonnie-Clyde cross-conjugal visitation, an enzymatic epoxide unzipping, and a Morbin rearrangement.